As someone who is a practical materialist, who does not believe we possess any supernatural spirit apart from the self-awareness generated in our brains, and who furthermore does not believe in any supernatural deities, my answer is a general no.
First, if the question assuming that "ultimate meaning" can only exist in a context of some kind of afterlife (eternal or otherwise), then the deck is stacked, and no answer apart from that would be conceivable. The issue ultimately relates not to the afterlife at all, but to what meaning and purpose people come to think about their own lives and the lives of others.
Christian tradition talks about life after death quite a bit, in fact a lot of faith communities focus on the saving act of God in Christ is to keep our toes out of the fires of hell.